Pharmacotherapy versus T lymphocytes for CMV

Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation

The role of CD4+ T cells in the control of persistent viral infections beyond the provision of cognate help remains unclear. We used polychromatic flow cytometry to evaluate the production of the cytokines interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-2, the chemokine macrophage inflammatory protein (MIP)-1beta, and surface mobilization of the degranulation mar...

Frequencies of circulating cytolytic, CD45RA+CD27-, CD8+ T lymphocytes depend on infection with CMV.

Viral infections may cause serious disease unless the adaptive immune system is able to clear the viral agents through its effector arms. Recent identification and functional characterization of subpopulations of human CD8(+) T cells has set the stage to study the correlation between the appearance of particular subsets and common viral infections during childhood, i.e., EBV, CMV, varicella-zos...

CMV T Lymphocytes + , CD 8 − CD 27 + CD 45 RA Frequencies of Circulating

Pretransplantation CMV-specific T cells protect recipients of T-cell-depleted grafts against CMV-related complications.

We have studied cytomegalovirus (CMV) immunity in 17 CMV-positive recipients of T-cell-depleted or T-cell-replete grafts. In recipients of T-cell-replete grafts, the patient's CMV-specific T-cell response was completely ablated. Because primary anti-CMV responses were rare during the first year, immunity depended essentially on the transfer of donor CMV-specific T cells and, therefore, on the C...

Stem cell therapy versus T lymphocytes: friend or foe?

Given the recent findings that transplanted therapeutic stem cells may die within days of implantation, soluble factors are now thought to play a key role in the outcome of stem cell therapies [1, 2]. This brings focus on pivotal immune regulatory switches within the host and is especially relevant where the source of therapeutic stem cell influences therapeutic efficacy. By comparing human bon...